Clearance of topically applied PVP-iodine as solution or gel in periodontal pockets in men

OBJECTIVES The aim of the study was to investigate the clearance of PVP-iodine applied as a gel or solution in periodontal pockets. METHODS Teeth of 12 subjects with at least eight periodontal pockets of �5 mm probing depth were isolated with a rubber dam to allow contamination-free access to the pockets. In each subject, three pockets were filled with PVP-iodine gel (10%) and three with PVPiodine solution (10%). One pocket of each subject without iodine application served as a negative control. The treatment allocation was assigned randomly. Any excess material was removed subsequently. After 1, 5 and 15 min, a paper point was used to collect the sulcus liquid and the concentration of PVPiodine was chemically determined. In addition, PVP-iodine gel was administered into 12 periodontal pockets immediately after sub-gingival ultrasound debridement and the concentration of PVP-iodine was determined after 1 min. RESULTS Descending concentrations of PVP-iodine were determined at 1, 5 and 15 min after the application. No PVP-iodine was found in the pockets serving as negative controls. The mean concentrations of the gel and solution were 6.14 �g/ml and 4.44 �g/ml (1 min; p � 0.028), 3.20 �g/ml and 1.44 �g/ml (5 min; p � 0.126), 0.69 �g/ml and 0.23 �g/ml (15 min; p � 0.019), respectively. In the pockets with previous debridement the mean concentration was 1.68 ± 1.97 �g/ml. CONCLUSION The application of PVP-iodine gel in periodontal pockets allows a prolonged remnant effect as compared to that of the solution formula. DOI: https://doi.org/10.3109/00016357.2011.640276 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-100000 Accepted Version Originally published at: Sahrmann, Philipp; Sener, Beatrice; Ronay, Valerie; Attin, Thomas; Schmidlin, Patrick R (2012). Clearance of topically-applied PVP-iodine as a solution or gel in periodontal pockets in men. Acta Odontologica Scandinavica, 70(6):497-503. DOI: https://doi.org/10.3109/00016357.2011.640276 Clearance of topically applied PVP-iodine as solution or gel in periodontal pockets in men Philipp Sahrmann*, Beatrice Sener*, Valerie Ronay*, Thomas Attin*, Patrick R Schmidlin* * Clinic for Preventive Dentistry, Periodontology and Cariology, Center for Dental and Oral Medicine and Maxillofacial Surgery, University of Zurich, Switzerland Running title: Clearance of PVP-iodine Correspondence: PD Dr. Patrick Schmidlin Clinic for Preventive Dentistry, Periodontology and Cariology Phone +41 44 634 32 84 FAX: +41 44 634 43 08 E-mail [email protected]